I couldn't find any definitive information on the renew22.com of Penndot district 12 sites, so I hit Penndot's home page on Monday and sent an email. Yesterday, a contact in District 12 left me a message. Kudos to Penndot for the quick return call and info.

Route 22, in both directions, is restricted to 1 lane from Hanna's Town Road (where Liberty Trucking is at the bottom of the hill past the Climax) to 119. There will be no closures, 1 lane will always be open, so traffic should always move. It might get a little slow through the work zone if you get behind a truck, or when the work zone is active, but sounds like it will keep moving.